| T3858 |
Macranthoidin A
|
|
Others
|
|
Macranthoidin A has anti-inflammation activity. |
| T4S1114 |
Dryocrassin ABBA
|
Dryocrassin |
Influenza Virus
,
Antibacterial
|
|
Dryocrassin ABBA (Dryocrassin) is a flavonoid natural product derived from Dryopteris crassirhizoma, with antiviral and antibacterial activities. |
| T1560 |
Prednisolone
|
Predonine,Hydroretrocortine,Metacortandralone |
Glucocorticoid Receptor
,
Endogenous Metabolite
|
|
Prednisolone (Hydroretrocortine) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. |
| T5784 |
Topotecan
|
NSC 609669,SKF 104864A |
Topoisomerase
,
Autophagy
|
|
Topotecan (NSC-609669) is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases. |
| T1611 |
Isotretinoin
|
13-cis-Retinoic acid |
Retinoid Receptor
,
Endogenous Metabolite
,
Autophagy
|
|
Isotretinoin (13-cis-Retinoic acid) binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. Isotretinoin is a naturall... |
| T1326 |
Gentamicin sulfate
|
SCH9724,Gentamycin sulfate,NSC-82261 |
ribosome
,
DHFR
,
Antibacterial
,
Antibiotic
|
|
Gentamicin sulfate (SCH9724) is a wide-spectrum, aminoglycoside antibiotic used to inhibit protein synthesis in sensitive organisms. |
| T0974 |
Novobiocin Sodium
|
Albamycinsodium,Cathomycin,Albamycin |
Potassium Channel
,
DNA gyrase
,
Topoisomerase
,
Antibacterial
,
Antibiotic
,
ABC
,
Autophagy
|
|
Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure sim... |
| T5283 |
NADH disodium salt
|
Disodium NADH,NADH, disodium salt hydrate |
Others
,
Endogenous Metabolite
|
|
NADH disodium salt (Disodium NADH) hydrate is the reduced form of nicotinamide adenine dinucleotide (NAD) that can donate electrons as part of a reducing reaction. In that process, NADH disodium salt hydrate becomes oxid... |
| T6194 |
Fidaxomicin
|
Tiacumicin B,OPT-80,Clostomicin B1,PAR-101 |
Apoptosis
,
DNA/RNA Synthesis
,
Antibacterial
,
Antibiotic
|
|
Fidaxomicin (Tiacumicin B) is a semisynthetic macrolide antibiotic used to treat Clostridium difficile-associated diarrhea in adults. Fidaxomicin has minimal systemic absorption and has not been linked to serum enzyme el... |
| T2719 |
Succinic acid
|
Asuccin,Amber acid,1,2-Ethanedicarboxylic acid,Wormwood acid,Butanedioic acid,1,4-Butandioic Acid |
Endogenous Metabolite
|
|
Succinic acid (1,2-Ethanedicarboxylic acid) is a water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is al... |
| T3417 |
Amentoflavone
|
Didemethyl-ginkgetin,Amenthoflavone,3',8''-Biapigenin |
Apoptosis
,
P450
,
Phospholipase
,
Reactive Oxygen Species
,
Opioid Receptor
,
COX
,
Antibacterial
,
RSV
,
Antifungal
|
|
Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhib... |
| T2755 |
Rhoifolin
|
Apigenin-7-O-rhamnoglucoside,Apigenin 7-O-neohesperidoside,Rhoifoloside |
Others
,
p38 MAPK
,
NF-κB
,
transporter
,
IGF-1R
,
Autophagy
|
|
Rhoifolin (Apigenin 7-O-neohesperidoside) is extracted from Turpinia arguya Seem dried leaves. |
| T3912 |
Saikosaponin B1
|
|
Others
|
|
Saponin activator. Activates release of Prostaglandin E2 in vitro. Anti-inflammatory agent. Orally active. Active in vivo and in vitro. |
| T13092 |
Tauro-Obeticholic acid
|
|
FXR
|
|
Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR). |
| TQ0288 |
Hexahydrocurcumin
|
|
Reactive Oxygen Species
,
ROS
,
COX
|
|
Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1. |
| T4912 |
Jatrorrhizine chloride
|
Yatrorhizine chloride,Neprotine chloride |
Others
,
5-HT Receptor
,
OCT
,
Antibacterial
,
AChE
|
|
Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 h... |
| TN2429 |
Capsiate
|
|
Antioxidant
,
TRP/TRPV Channel
|
|
Capsiate is an orally active TRPV1 agonist, a non-irritating capsaicin analog that acts as an antiallergic agent with anti-inflammatory, antioxidant, hypoglycemic, and inhibitory angiogenic activity. |
| T7064 |
Valproic Acid
|
Sodium valproate,2-Propylpentanoic Acid,VPA,Depakine,2-Propylvaleric Acid |
Mitophagy
,
Gamma-secretase
,
HIV Protease
,
GABA Receptor
,
Sodium Channel
,
HDAC
,
Autophagy
|
|
Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that inhibits HDAC1 activity, induces HDAC2 degradation, and is orally active. Valproic Acid can be used in epilepsy and bipolar disorder research. |
| T11060 |
DMAPT
|
Dimethylamino Parthenolide |
NF-κB
|
|
DMAPT (Dimethylamino Parthenolide) is a water-soluble analogue of Parthenolide (PTL). It is an orally active NF-κB inhibitor with an LD50 of 1.7 μM on primary acute myeloid leukemia cells. |
| T0948L |
Corticosterone
|
17-Deoxycortisol,11β,21-Dihydroxyprogesterone,Kendall's compound B,Corticosterone (From plants) |
Glucocorticoid Receptor
,
Endogenous Metabolite
|
|
Corticosterone (Kendall's compound B) is an adrenocortical steroid with salocorticoid and glucocorticoid activity that is orally active. Corticosterone is involved in the regulation of energy, immune responses, and stres... |
| TJS2216 |
Aurantiamide acetate
|
Asperglaucide |
Cysteine Protease
|
|
Aurantiamide acetate (Asperglaucide) was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selective and orally active cathepsin inhibitor. Aurantiamide aceta... |
| T3S2007 |
MRE-269
|
MRE 269,ACT-333679,MRE269 |
Prostaglandin Receptor
|
|
MRE-269 (ACT-333679) is an orally available and long-acting prostacyclin receptor agonist prodrug. MRE-269(ACT-333679) is used for the treatment of pulmonary arterial hypertension. MRE-269(ACT-333679) is an active metabo... |
| T16442 |
PCO371
|
2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl- |
Thyroid hormone receptor(THR)
|
|
PCO371 (2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-) is an orally active full agonist of parathyroid hormon... |
| T0883 |
Tramiprosate
|
Homotaurine,3-Amino-1-propanesulfonic acid,Alzhemed |
Beta Amyloid
,
GABA Receptor
|
|
Tramiprosate (Alzhemed) is an orally active, blood-brain-barrier-crossing, naturally occurring amino acid found in a variety of red seaweeds that binds soluble Aβ and maintains it in a non-protofibrillar form.It is a GAB... |
| T40615 |
N,N'-Dimethylthiourea
|
DMTU |
Antioxidant
|
|
N,N'-Dimethylthiourea (DMTU) (DMTU), isolated from Allii Sativi Bulbus, is an orally active scavenger of hydroxyl radical ( OH) and blocks OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects a... |
| T6491 |
(-)-(S)-Equol
|
(−)-Equol,Equol,4',7-Dihydroxyisoflavan,4',7-Isoflavandiol |
Estrogen Receptor/ERR
,
Estrogen/progestogen Receptor
,
Endogenous Metabolite
|
|
(-)-(S)-Equol (4',7-Dihydroxyisoflavan) is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with potential chemoprotective a... |
| T4954L |
Smilagenin
|
PYM50028,Cogane,AI3-44895,PYM 50028 |
|
|
Smilagenin is an orally active inducer of nonpeptide neurotrophic factor. It also prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons, and by MPTP in a mouse model of Parkinson's disease. |
| T68746 |
Chaetochromin
|
|
|
|
Chaetochromin also known as 4548-G05 and NSC 345647, is an orally active, small-molecule, selective agonist of the insulin receptor. It has potent and long-lasting antidiabetic activity in vivo in mice. |
| T38557 |
Chitotriose trihydrochloride
|
|
|
|
Chitotriose trihydrochloride is an orally active chitooligosaccharide known for its antioxidant properties. It effectively inhibits the hydroxylation of benzoate to salicylate by H 2 O 2 in the presence of Cu 2+, with an... |
| T61171 |
Cyclo(his-pro) TFA
|
|
|
|
Cyclo(his-pro) TFA, an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone, has shown inhibitory effects on NF-κB nuclear accumulation. Additionally, it possesses the ability to cross the... |
| T60741 |
Dihydrocapsiate
|
|
|
|
Dihydrocapsiate is a compound of capsinoid family that can be used in metabolism diseas research. Dihydrocapsiate is an orally active agonist of TRPV1 [1]. |
| TN2360 |
Falcarinol
|
Falcarinol,Panaxynol |
HSP
|
|
Falcarinol, also known as Panaxynol, is a naturally occurring compound that acts as an orally active inhibitor of Hsp90. It effectively targets both the N-terminal and C-terminal regions of Hsp90, displaying high selecti... |
| T75508 |
Bleomycin A5
|
|
|
|
Bleomycin A5 (Pingyangmycin), a glycopeptide antibiotic that is orally active, functions as an antineoplastic agent, an apoptosis inducer, and a bacterial metabolite [1] [2]. |
| T72236 |
Erythro-Austrobailignan-6
|
|
|
|
Erythro-Austrobailignan-6, an orally active anti-cancer agent, inhibits DNA topoisomerase I and II activity, induces cell apoptosis, and enhances the phosphorylation of p38 and JNK. |
| T38441 |
Manzamine A hydrochloride
|
|
|
|
Manzamine A hydrochloride is an orally active beta-carboline alkaloid that exhibits specific inhibitory effects on GSK-3β (IC50 = 10.2 μM) and CDK-5 (IC50 = 1.5 μM). Additionally, it targets vacuolar ATPases, leading to ... |
| T72961 |
Falcarindiol
|
法卡林二醇 |
|
|
Falcarindiol, an orally active polyacetylenic oxylipin, not only activates PPARγ, enhancing ABCA1 expression—a cholesterol transporter—but also induces apoptosis and autophagy. This compound exhibits anti-inflammatory, a... |
| T77988 |
Phenyl sulfate
|
Phenyl hydrogen sulfate |
Endogenous Metabolite
|
|
Phenyl sulfate, an orally active metabolite derived from gut microbiota, induces albuminuria and podocyte damage in diabetes experimental models. It serves as a potential disease marker and therapeutic target for diabeti... |
| T81222 |
Salvifaricin
|
|
|
|
Salvifaricin, an orally active diterpenoid isolated from Salvia leucantha Cav. and Salvia hispanica L., significantly lowers fasting blood glucose and serum triglyceride (TG) levels, exhibiting an anti-diabetic effect [1... |
| T75427 |
Cholic acid sodium hydrate
|
|
|
|
Cholic acid sodium hydrate, a primary bile acid synthesized in the liver and typically conjugated with glycine or taurine, plays a crucial role in facilitating fat absorption and cholesterol excretion. This compound is o... |
| T15949 |
Mahanimbine
|
|
AChE
|
|
Mahanimbine is found in the roots, leaves and stems of Murraya koenigii and is an orally active alkaloid extracted from Murraya koenigii. Bifidobacterium bifidum leaves on histopathological changes in pancreatic beta cel... |
| T75433 |
Norisoboldine hydrochloride
|
|
|
|
Norisoboldine hydrochloride, an orally active aryl hydrocarbon receptor (AhR) agonist and a prominent isoquinoline alkaloid found in Radix Linderae, is utilized for research purposes in the study of Rheumatoid Arthritis ... |
| T60692 |
Masoprocol
|
|
|
|
Masoprocol (meso-Nordihydroguaiaretic acid) is a potent and orally active inhibitor of lipoxygenase. Masoprocol exhibits antihyperglycemic activity that has the potential for the type II diabetes research. In vivo, Masop... |
| T21266 |
Quinine sulfate
|
|
|
|
Quinidine is an antiarrhythmic agent. Quinidine is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine is also a blocker of K + channel with an IC 50 of 19.9 μM. Quinidine has potential to be used ... |
| T81324 |
Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside
|
|
|
|
Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside, an orally active phenolic compound extracted from the Geranium species, exhibits anti-inflammatory properties. It shows promise for use in treatments involving edema and... |
| T81117 |
Spilanthol
|
|
|
|
Spilanthol, an orally active compound with analgesic, neuroprotective, antioxidant, antimutagenic, anti-cancer, anti-inflammatory, antimicrobial, and insecticidal properties, facilitates the induction of cAMP, thereby in... |
| T75527 |
Chrexanthomycin C
|
|
|
|
Chrexanthomycin C, an orally active marine-derived natural product, exhibits significant bioactivities and shows a binding affinity for DNA [(G4C2)4 G4] with a dissociation constant (Kd) of 2.8 mM. This compound holds po... |
| T73074 |
Phanginin A
|
|
|
|
Phanginin A, a potent and orally active activator of salt-induced kinase 1 (SIK1), effectively inhibits gluconeogenesis, increases the expression of p-SIK1, and decreases the expression of p-CREB. By reducing blood gluco... |
| T79939 |
Quercetin 3-(6″-caffeoylsophoroside)
|
|
|
|
Quercetin 3-(6″-caffeoylsophoroside) is an orally active compound exhibiting α-amylase inhibitory activity, with an IC50 value of 73.66 μg/mL, and demonstrates antidiabetic effects through the reduction of oxidative stre... |
| T80007 |
Stevisalioside A
|
|
Phosphatase
|
|
Stevisalioside A (Compound 2), isolated from the roots of Stevia serrata, is an orally active antidiabetic agent that inhibits Protein Tyrosine Phosphatase 1B (PTP1B) with an IC50 value of 526.8 μM. It effectively lowers... |
| T75705 |
Pepstatin Trifluoroacetate
|
|
|
|
Pepstatin Trifluoroacetate (Pepstatin A), a specific and orally active aspartic protease inhibitor produced by actinomycetes, demonstrates inhibition efficacy with IC50 values of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM, a... |
